Dimethyl Sulfoxide
Apexbio Technology LLC Rifapentine 61379-65-5 10mM (in 1mL DMSO)
Rifapentine is an antibiotic compound employed in the treatment of pulmonary tuberculosis an infectious disease primarily caused by Mycobacterium tuberculosis Rifapentine inhibits bacterial RNA polymerase thereby preventing RNA synthesis essential for bacterial replication and survival In vitro studies demonstrate that rifapentine possesses potent activity against intracellular M tuberculosis residing within human macrophages with reported MIC values ranging from 0 015 to 0 06 mg/ml Preclinical research indicates rifapentine accumulates extensively in host cells achieving higher intracellular concentrations than structurally related rifampin Clinically rifapentine administration schedules involve twice-weekly doses during the intensive phase of tuberculosis therapy followed by weekly dosing in the continuation phase Rifapentine is commonly investigated in pharmacological studies to assess efficacy and optimize dosing regimens in pulmonary tuberculosis treatment
Apexbio Technology LLC ABT-263 (Navitoclax) 923564-51-6 10mM (in 1mL DMSO)
ABT-263 (Navitoclax CAS 923564-51-6) is an orally bioavailable small molecule inhibitor targeting anti-apoptotic proteins of the Bcl-2 family including Bcl-2 Bcl-xl and Bcl-w By disrupting interactions between these anti-apoptotic factors and pro-apoptotic proteins (Bim Bad Bak) ABT-263 promotes activation of caspase-dependent apoptotic pathways resulting in programmed cell death This compound is utilized extensively in oncology research to explore apoptotic mechanisms and evaluate antitumor efficacy in various cancer models
Apexbio Technology LLC PCI-32765 (Ibrutinib) 936563-96-1 10mM (in 1mL DMSO)
PCI-32765 (Ibrutinib) is a small-molecule inhibitor targeting Bruton s tyrosine kinase (BTK) a cytoplasmic kinase integral to B-cell receptor (BCR) signaling By covalently binding to BTK active sites PCI-32765 disrupts downstream signaling cascades essential for B-cell maturation and activation Dysfunction or inhibition of BTK correlates with impaired B-cell development and reduction in autoantibody production PCI-32765 is commonly utilized in biomedical research to explore BTK-dependent signaling pathways elucidate molecular mechanisms underlying B-cell mediated disorders and examine therapeutic potential in B-cell malignancies and autoimmune models
Apexbio Technology LLC Nexturastat A 1403783-31-2 10mM (in 1mL DMSO)
Nexturastat A (CAS 1403783-31-2) is a selective small-molecule inhibitor of histone deacetylase 6 (HDAC6) It displays potent inhibitory activity against HDAC6 with an IC50 of 5 2 nM While predominantly targeting HDAC6 Nexturastat A also exhibits moderate inhibitory effects on other HDAC isoforms (HDAC1-5 and 7-11) at low micromolar concentrations In cell-based studies including mouse B16 melanoma cell lines Nexturastat A has shown antiproliferative properties and induction of apoptosis Due to its selective HDAC6 inhibition Nexturastat A is utilized in cancer research focusing on epigenetic regulation and therapeutic development
Apexbio Technology LLC Tasquinimod 254964-60-8 10mM (in 1mL DMSO)
Tasquinimod (CAS 254964-60-8) is an orally bioavailable quinoline-3-carboxamide compound with antiangiogenic and antitumor properties It modulates angiogenesis primarily through dual inhibition of S100A9/TLR4 signaling in myeloid-derived suppressor cells (MDSCs) and downregulation of HIF-1 and VEGF expression in tumor and endothelial cells It also enhances thrombospondin-1 (TSP-1) expression further suppressing neovascularization Preclinical studies in human prostate cancer xenograft models indicate significant antineoplastic activity particularly in combination with docetaxel radiation therapy or androgen-depletion strategies suggesting its therapeutic potential for castration-resistant prostate cancer (CRPC)
Apexbio Technology LLC SU6656 330161-87-0 10mM (in 1mL DMSO)
SU6656 (CAS 330161-87-0) is a selective small-molecule inhibitor targeting Src family tyrosine kinases enzymes involved in pathways promoting cellular survival proliferation angiogenesis and invasion In NIH 3T3 cells SU6656 suppresses PDGF- and Src-induced cell cycle progression and c-Myc expression In UT-7/TPO leukemia cells SU6656 induces cell cycle arrest with increased DNA content and elevates CD41/CD61 surface expression Additionally SU6656 enhances radiation-mediated endothelial apoptosis and vascular disruption by inhibiting Src-dependent Akt phosphorylation suggesting its potential utility in antitumor angiogenesis research
Apexbio Technology LLC N6022(Synonyms: N6022, GSNOR inhibitor N6022, N-6022, N 6022, GSNOR Inhibitor N-6022, CAS 1208315-24-5, GSNORi N6022), 10mM (in 1mL DMSO), CAS: 1208315-24-5.
N6022 (CAS 1208315-24-5) is a selective reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) an enzyme involved in regulating the levels of S-nitrosoglutathione (GSNO) Inhibition of GSNOR leads to elevated GSNO concentrations promoting vasodilatory and anti-inflammatory effects In biochemical assays N6022 exhibits IC50 values of 8 nM (GSNO reduction assay) and 32 nM (HMGSH oxidation assay) with corresponding Ki values of 2 5 nM and 3 1 nM respectively Due to its selectivity profile and potency N6022 has entered clinical evaluation for inflammatory pulmonary conditions
Apexbio Technology LLC UMI-77(Synonyms: UMI 77, UMI77, UMI-77 Mcl-1 inhibitor, Mcl-1 inhibitor UMI-77, 518303-20-3), 10mM (in 1mL DMSO), CAS: 518303-20-3.
UMI-77 (CAS 518303-20-3) is a small-molecule inhibitor targeting the anti-apoptotic protein Myeloid cell leukemia-1 (Mcl-1) a member of the Bcl-2 protein family implicated in apoptotic regulation and cell survival signaling Biochemical assays demonstrate that UMI-77 binds selectively to the BH3-binding groove of Mcl-1 protein competing effectively against pro-apoptotic BH3 peptides (Ki 0 49 M) Additionally UMI-77 disrupts the interaction of Mcl-1 with pro-apoptotic factors such as Bax (IC50 1 43 M) promoting apoptosis in cancer cells Preclinical studies on pancreatic cancer cell lines and BxPC-3 xenograft mouse models show that UMI-77 suppresses tumor growth and induces apoptotic cell death highlighting its value as a research tool for studying apoptosis-related oncogenic pathways
Apexbio Technology LLC Trichostatin A (TSA) 58880-19-6 10mM (in 1mL DMSO)
Trichostatin A (TSA CAS 58880-19-6) is a histone deacetylase (HDAC) inhibitor and antifungal antibiotic isolated from microbial sources TSA acts by reversibly inhibiting HDAC enzymes in a noncompetitive manner leading to increased acetylation of histones particularly histone H4 In mammalian cell cultures TSA treatment results in G1 and G2 phase arrest induction of differentiation and reversion of transformed cellular phenotypes In human breast cancer cell lines TSA inhibits proliferation (IC50 124 4 120 4 nM) and induces hyperacetylation of histone proteins highlighting its utility as a tool compound for investigating epigenetic regulation and oncology-related mechanisms
Apexbio Technology LLC RG 108 48208-26-0 10mM (in 1mL DMSO)
RG 108 (CAS 48208-26-0) is a small-molecule inhibitor of DNA methyltransferases (DNMTs) It acts by directly blocking DNMT activity without forming covalent enzyme-adducts leading to DNA demethylation and consequent reactivation of epigenetically silenced tumor suppressor genes However RG 108 treatment does not affect methylation status of centromeric satellite DNA sequences In cellular models RG 108 promotes reprogramming efficiency especially enhancing induction of pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs) It is useful for studying epigenetic gene regulation tumor suppression pathways and cellular reprogramming mechanisms
Apexbio Technology LLC PF-670462 950912-80-8 10mM (in 1mL DMSO)
PF-670462 (CAS 950912-80-8) is a selective inhibitor of casein kinase 1 (CK1) isoforms CK1 and CK1 serine/threonine kinases involved in circadian rhythm regulation It exhibits inhibitory activity toward CK1 and CK1 with IC50 values of approximately 80 nM and 13 nM respectively In cellular models co-transfected with GFP-tagged PER3 and human CK1 PF-670462 blocks nuclear translocation of PER3 In primary fibroblasts from wild-type mice it dose-dependently prolongs circadian cycle length PF-670462 serves as a useful chemical tool for studying CK1-mediated modulation of circadian rhythms
Apexbio Technology LLC LB42708 226929-39-1 10mM (in 1mL DMSO)
LB42708 (CAS 226929-39-1) is a selective small-molecule inhibitor of farnesyltransferase (FTase) belonging to a non-peptidic pyrrole-based class It blocks FTase-mediated farnesylation of H-Ras N-Ras and K-Ras4B demonstrated by low nanomolar IC50 values (0 8 nM 1 2 nM and 2 nM respectively) LB42708 shows minimal inhibitory effect on geranylgeranyltransferase I In vitro studies indicate inhibition of Ras-driven signaling pathways decreasing Ras activation and subsequently suppressing VEGF-stimulated endothelial proliferation and migration Researchers use LB42708 in oncology and inflammation studies exemplified by reduced tumor growth in Ras-mutant HCT116 and wild-type Caco-2 xenograft models
Apexbio Technology LLC SU5416 204005-46-9 10mM (in 1mL DMSO)
SU5416 (CAS 204005-46-9) also known as Semaxanib is a small molecule inhibitor designed to block vascular endothelial growth factor receptor (VEGFR2) particularly targeting Flk-1/KDR receptor tyrosine kinase signaling SU5416 effectively inhibits VEGF-induced phosphorylation of Flk-1 thereby interfering with endothelial cell proliferation angiogenesis and subsequent tumor vascularization Preclinical studies demonstrated suppression of tumor growth accompanied by angiogenesis inhibition Additionally SU5416 acts as an agonist of the aryl hydrocarbon receptor (AHR) modulating immune responses via induction of indoleamine 2 3-dioxygenase (IDO) and regulatory T cell differentiation These properties suggest potential utility not only in cancer research but also in investigating autoimmune conditions and transplant tolerance
Medchemexpress LLC Ru.521 10Mm Dmso Solid 1Nl | HY-114180-10MM DMSO SOLID
Ru.521 10Mm Dmso Solid 1Nl